{"iri":"https://folio.openlegalstandard.org/R7lCj2dvGu7618ONPPEpJB","label":"Systemic Sclerosis","sub_class_of":["https://folio.openlegalstandard.org/RBJ0dgV4Z2Xk7aGfJt2nSj7"],"parent_class_of":[],"is_defined_by":null,"see_also":[],"comment":null,"deprecated":false,"preferred_label":"Scleroderma","alternative_labels":["Autoimmune Connective Tissue Disorder","Progressive Systemic Sclerosis"],"translations":{},"hidden_label":null,"definition":"Systemic sclerosis (also known as scleroderma) constitutes a spectrum of disease in which thickening of the skin is the clinical hallmark. Raynaud's phenomenon, often medically severe and progressive, is present frequently and may be the peripheral manifestation of a vasospastic abnormality in the heart, lungs, and kidneys. The CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) is a variant that may slowly progress over years to the generalized process, systemic sclerosis.","examples":[],"notes":[],"history_note":null,"editorial_note":null,"in_scheme":null,"identifier":null,"description":null,"source":null,"country":null}