Chronic Pulmonary Hypertension Persistent Pulmonary Hypertension Pulmonary Arterial Hypertension Chronic pulmonary hypertension is a condition characterized by persistently high blood pressure in the pulmonary arteries, which carry blood from the heart to the lungs. This condition leads to increased workload on the right side of the heart and can cause symptoms such as shortness of breath, fatigue, and chest pain.